QuickView for arginine-rich protein;jsessionid=4387F96F21D34C07E004F12BE119C2DE;jsessionid=923AF45BD307AE814279F7AF2A2DE060 (gene)

Gene Symbol:

MANF Homo sapiens

Full name:

mesencephalic astrocyte derived neurotrophic factor

Synonyms:

ARMET, ARP, mesencephalic astrocyte-derived neurotrophic factor, arginine-rich, mutated in early stage tumors

Genomic Location:

Chr 3: 51397743-51401815

Description:

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphism...

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The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CMYB_01 ,  OCT1_05 ,  ARNT_01 ,  YGTCCTTGR_UNKNOWN ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  MAX_01 ,  YATTNATC_UNKNOWN ,  XBP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  ARNT_02 ,  MYB_Q5_01 ,  GCCATNTTG_YY1_Q6 ,  OCT1_Q5_01 ,  OCT_C ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  AR_Q6 ,  OCT1_Q6 ,  CAGGTA_AREB6_01 ,  PXR_Q2 ,  MYCMAX_01 ,  AREB6_01 ,  USF_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  PIT1_Q6 ,  T3R_Q6 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  ER_Q6_02 ,  MMEF2_Q6 ,  AACTTT_UNKNOWN ,  USF_02

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Cytogenetic Map:

3p21.2

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